published by KARGER , Basel 2002, supported bySERONO SYMPOSIAread Reviews of this book
by Professor Siegfried Schwarz, M.D., Laboratory of Molecular Endocrinology
A FEW RELATED LINKS
1. LIGANDS Small Molecules PDB# PDBsum Genecards Locus OMIM# 1.1 Calcium and Non-Peptidic Small Molecules Ca + Calmodulin 1CLM *** CALM1 14q24 114180 Ca + E-Selectin 1ESL *** SELE 1q23 131210 Mellitin 2MLT Daunomycin + ssDNA 110D Mitomycin + dsDNA 199D Transthyretin + T3 1THA *** TTR 18q11.2 176300 1.2 Peptide Hormones Acidic Fibroblast Growth Factor 1AFG *** FGF1 5q31 131220 Basic Fibroblast Growth Factor 1BFG *** FGF2 4q25-27 134920 Epidermal Growth Factor 1EPI *** EGF 4q25 131530 Granulocyte Colony Stimulating Factor 1BFD *** CSF3 17q11.2 138970 Glucagon 1-29 1GCN *** GCG 2q36 139030 Human Chorionic Gonadotropin-ß (hCG) 1HRP *** CGB 19q13 118860 Luteinizing Hormone-ß LHB 19q13.32 152780 alpha-Subunit CGA 6q21.1 118850 Growth Hormone (HGH) 3HHR *** GH1 17q22-24 139250 Insulin 1APH *** INS 11p15.5 176730 mutated Insulin "Chicago" 1HIQ *** - - - Insulin-like Growth Factor (IGF-1) 1GF1 *** IGF1 12q22 147440 Interferon-gamma (IFNg) 1RFB *** IFNG 12q14 147570 Interleukin 1ß (IL-1ß) 2MIB *** IL1B 2q14 147720 Nerve Growth Factor (NGß) 1BET *** NGFB 1p13.1 162030 Oxytocin 1XY1 *** OXT 20p13 167050 Arginin-Vasopressing (AVP) (= Oxytocin) + Neurophysin 2 1NPO AVP 20p13 192340 Parathyroid hormone 1-37 (PTH) 1HPH *** PTH 11p15.3 168450 Platelet-Derived Growth Factor (PDGF) 1PDG *** PDGFA 7p22 173430 PDGFB 22q12.3 190040 Transforming Growth Factor-alpha (TGFa) 2TGF *** TGFA 2p13 190170 Transforming Growth Factor-beta (TGFß) 1TFG *** TGFB1 19q13.1 190180 Tumor Necrosis Factor-alpha (TNFa) 1TNF *** TNF 6p21.3 191160 TNFa + Receptor 1TNR *** TNFRSF1A 12p13.2 191190 1.3 Peptide Toxins Bungarotoxin + nicotinic AcCh-Receptor 1ABT *** CHRNA1 2q24 100690 Charybdotoxin (Scorpion) 1PTX *** KCNQ1 11p15.5 607542 Choleratoxin (B-subunit) 2CHB *** GNAS 20q13.2 139320 Sarafotoxin 1SRB *** EDNRB 13q22 131244 W-Conotoxin GVIa 1OMC *** GRIN1 9q34 138249 LIGAND-BINDING PROTEINS Large Molecules 2. Enzymes Carbonic anhydrase + bicarb. 1CAM *** CA1 8q22 114800 Citrate synthase 5CSC *** CS 12p11 118950 Cyclin-dependent Kinase 2 (CdK2) 1B38 *** CDK2 12q13 116953 CdK2 + Cyclin A 1QMZ *** CCNA1 ? 604036 DNA polymerase (KLENOW fragt.) + dCTP 1KFD *** POLD1 19q13.3 174761 DNA sliding clamp 1B77 *** HNPCC 2p22-p21 120435 HIV1-protease+ non-pept.INH 4PHV *** - - - HIV2-protease+ renin-INH-peptide 2PHV *** - - - HIV1-reverse transcriptase + nevirapin 3HVT *** - - - P450 SCC Enzyme + Hem + CAM 1SCC *** CYP11A 15q23 118485 Phospholipase A2 (secretory) 1KVO *** PLA2G2A 1p35 172411 1BP2 *** Renin + peptidic INH 1SMR *** REN 1q32 179820 RNase/Angiogenin-Inhibitor (RAI) 1A4Y *** RNH 11p15.5 173320 RNase 2BNH *** ANG=RNASE5 14q11 105850 3,20-Steroid dehydrogenase + Carbenoxn. 1HDC *** HSD3B2 1p13.1 201810 3. Membrane Receptors, Channels ATP Synthase F1 unit 1BMF *** ATP5A1 18q12-q21 164360 hCG Receptor + hCG 1HRP *** LHCGR 2p21 152790 HGH Receptor + HGH 3HHR *** GHR 5p13 600946 GH1 17q22 139250 IL-4 Receptor + IL-2 1ILM *** IL2R 10p15 147730 IL2 4q26 147680 Porin 3POR *** VDAC1 5q31 604492 [Aquaporin 1-Tetramer] 1J4N *** AQP2 12q13 107777 Rhodopsin + Retinal 1BRD *** RHO 3q21 180380 TNFa Receptor + TNFa 1TNR *** TNFRSF1A 12p13.2 191190 4. Signal Transduction Proteins Calmodulin + myosin light chain kinase 1CDL *** MYLK 3cen-q21 600922 G-Protein inhibitory Gia + GTPgS 1GIA *** GNAI1 7q21 139310 G-Protein inhibitory Gia + GDP + Mg 1GFI *** GNAI1 7q21 139310 [G-Protein stimulatory Gsa GNAS1 20q13.2 139320] Insulin receptor tyrosin kinase 1IRK *** INSR 19q13.2 147670 Protein kinase A + ATP + peptid.INH 1ATP *** PRKAR2A 3p21.3-p21.2 176910 Ras p21 + GDP + Mg 1CRQ *** HRAS 11p15.5 190020 SH2 Domain + Peptide 1SPS *** - - - Transducin + GDP 1TAD *** GNAT1 3p21 139330 5. Multimodular Adhesion Proteins Cadherin Module 1NCG *** CDH1 16q22.1 192090 CD2, Immunoglobuline-like Module 1CDB *** CD2 1p13.1 186990 Fibronectin Type I-Module + RGD-Motif 1FBR *** FN1 2q34 135600 EGF-Module 1APO *** - - - 6. DNA-Binding Proteins DNA Polymerase (human) + dsDNA 1BPX *** POLB 8p11.2 174760 DNA Polymerase (T4 Phage) + dsDNA 1T7P *** - - - DNA polymerase (KLENOW fragt.) + dCTP 1KFD *** POLD1 19q13.3 174761 DNA sliding clamp 1B77 *** HNPCC 2p22-p21 120435 Endonuclease EcoRv (bacterial) 2RVE *** DNASE1 16p13.3 125505 Fab of antibody + TTT trinucleotide 1CBV *** SLEB1 1q41-q42 152700 Fos:Jun Protooncogen + dsDNA 1FOS *** FOS 14q24.3 164810 JUN 1p32 165160 GATA-Binding Protein + GATA-Box 1GAT *** GATA1 Xp11.23 305371 Glucocorticoid Receptor + dsDNA 1GLU *** GRL 5q31 138040 Histone Complex 1AOI *** H4F2 1q21 142750 Max + dsDNA 1HLO *** MAX 14q23 154950 MyoD + dsDNA 1MDY *** MYOD1 11q15.4 159970 NFkB + dsDNA 1SVC *** NFKB1 4q23 164011 Telomer-Binding Protein + RNA 1OTC *** TERF1 8q13 600951 Nucleosmal Complex + dsDNA 1AOI *** HIST1H1A 142709 Pit-1 + dsDNA 1AU7 *** POU1F1 3p11 173110 Progesterone Receptor + Progesterone 1A28 *** PGR 11q22 607311 RXR + T3R + dsDNA 2NLL *** RARA 17q12 180240 T3R 1BSX *** THRA 3p24.3 190160 SRY Protein + ssDNA 1HRY *** SRY Yp11.3 480000 Telomere-Binding Protein + RNA 1OTC *** TERF1 8q13 600951 TITF1 or Vnd or NKX2-1 1NK3 *** NKX2A 14q13 600635 p53 1TSR *** TP53 17p13.1 191170 7. Immunological Proteins Antibody, complete immunoglobulin G 1IGT *** 14q32.33 147100 Complement Component C5a 1C5A *** C5 9q34.1 120900 Cyclophilin + Cyclosporin 2RMA *** PPID 4q31.3 601753 Fab of antibody + TTT trinucleotide 1CBV *** SLEB1 1q41-q42 152700 Fab of antibody + Lysozyme 1BQL *** BTK Xq21.3-q22 300300 Fab of antibody + Progesterone 1DBB *** - - - Fab of antibody + Peptide 2IGF *** - - - Fab of antibody + Trisaccharide 1MFD *** - - - HIV gp120 core protein + CD4 + Fab 1GC1 *** CD4 12pter 186940 HLA-DR + Influenza Virus Hemagglutinin 1DLH *** HLA-DRA 6p21.3 142860 T Cell Receptor + HTLV1-Tax + HLA-A +ß2M 1AO7 *** TCRA 14q11.2 186880 8. Miscellaneous Macromolecules Apolipoprotein A1 1AV1 *** APOA1 11q23 107680 ß2-Crystallin 1BLB *** CRYBA1 17q11.1 123610 Collagen (Gly-Pro-Pro) 1BBE *** COL1A1 17q21.31 120150 Foot & Mouth Virus Disease Coat Protein 1BBT *** - - - GroEl Chaperone 1OEL *** HSPD1 ? 118190 Hemoglobin A 2HBC *** HBA1 16pter 141800 Proteasome 1PML *** PSMA5 1p13 176844 Spectrin Modules 2SPC *** SPTA1 1q21 182860 Ubiquitin 1AAR *** UBB 17p12-p11.1 191339