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Markus Nagl
Ao.Univ.Prof., Dr.med.univ.,
Facharzt für Hygiene und Mikrobiologie,
Arzt für Allgemeinmedizin,
Klinischer Prüfarzt
Tel. +43-(0)512-9003-70708
Fax. +43-(0)512-9003-73700
E-Mail. m.nagl@i-med.ac.at |
Research Interests, Publications, Teaching |
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Research Interests
Long-lived oxidants (chloramines) are produced by activated human granulocytes and monocytes. N-chlorotaurine, the main representative, is thought to be involved in termination of inflammation since it downregulates proinflammatory cytokines.
After synthesis of the pure sodium salt of N-chlorotaurine (NCT), we demonstrated its broad-spectrum microbicidal activity against bacteria, viruses, fungi, and protozoa. NCT may not only play a role in killing of pathogens at inflammatory sites, but it is also very well tolerated by human tissue and can be used in pharmacological doses as an antiseptic to treat infections of different body sites, e.g. conjunctivitis, otitis externa, sinusitis, purulently coated crural ulcers, urinary tract infections. Advantages are excellent tolerability as a body-own medication and broad-spectrum activity without development of resistance as an antiseptic.
Present research comprises basic science on the mechanisms of action and interactions as well as clinical studies on its therapeutical application.
 Innate Immunity: intracellular killing of pathogens by leukocytes
Function of oxidants in intracellular killing, direct activity of endogenous oxidants
(particularly N-chlorotaurine and other chloramines) against pathogens. Phagocytosis.
Clinical application of endogenous oxidants
Clinical trials on the tolerability and efficacy of N-chlorotaurine in topical treatment of infections, e.g. conjunctivitis, otitis and sinusitis, leg ulcer, cystitis.
Antimicrobial agents
In vitro and in vivo activity of antimicrobial agents (antibiotics, disinfectants ...) and interaction of these agents with innate immunity.
Botulism
Testing of human and non-human samples for Clostridium botulinum, especially detection of Botulinumtoxin.
Publications
Staff
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| Dr. Andreas Dimmer |
Dr.med. |
Phase II clinical trial on a special N-chlorotaurine formulation in treatment of epidemic keratoconjunctivitis |
| Windisch Andrea |
BMA |
since 10/09 |
| Moser Barbara |
Mag.rer.nat. |
since 05/04
Thesis: "N-chlorotaurine, an antimicrobial product of human leukocytes: Mechanisms
of action" |
| Pinna Anna |
MSc |
since 03/07
Thesis: "Further studies on the tolerability and activity of N-chlorotaurine" |
| Roland Arnitz |
Dr.med. since 04/04 |
10/02 – 03/04
Thesis: "Antifungal mechanisms of N-chlorotaurine" |
| Fiala Anna |
cand.med. |
01/04 – 01/07
Thesis: "The role of lipopolysaccharide in the gut" |
| Kröss Eva |
cand.rer.nat. |
11/05 – 06/07
Diploma in microbiology: "Microbicidal activity of N-chlorotaurine in the presence of
corticoids" |
| Martini Catharina |
cand.med. |
11/05 – 08/08
Thesis: "Microbicidal activity of N-chlorotaurine combinations" |
| Walther Christoph |
cand.med. |
05/07 – 03/08
Thesis: "Determination of taurine concentration after application of N-chlorotaurine" |
Teaching:
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