CV of project leader (Prof. Dr. Werner Sieghart)
| 1963-1969 |
study of chemistry at the University of Vienna |
| 1973 |
PhD in Biochemistry |
| 1976-1978 |
Postdoctoral Fellow and Research Associate at the Dept. Pharmacol. Yale University (Paul Greengard) |
| 1978-1980 |
Assistant professor at the Section Biochem. Psychiatry, Univ. Clinic Psychiatry |
| 1980-2001 |
Chief of Section Biochem. Psychiatry, Univ. Clinic Psychiatry, Vienna, and Chief of a Clinical Chemistry Lab performing determinations of drugs of abuse, lithium, hormones and anticonvulsants for the University Clinic for Psychiatry, Vienna |
| 1982 |
Associate Prof. in Neurobiochemistry |
| 2002 |
Full Professor for Biochemical and Molecular Pharmacology of the Nervous System and Head of Division for Biochemistry and Molecular Biology, Center for Brain Research, Medical University Vienna |
Selected Publications
Rivas FM, Stables JP, Murphree L, Edwankar RV, Edwankar CR, Huang S, Jain HD, Zhou H, Majumder S, Sankar S, Roth BL, Ramerstorfer J, Furtmüller R, Sieghart W, Cook JM (2009) Antiseizure activity of novel gamma-aminobutyric acid(A) receptor subtype-selective benzodiazepine analogues in mice and rat models. J. Med. Chem. 52: 1795-1798.
Savic MM, Clayton T, Furtmüller R, Gavrilovic I, Samardzic J, Savic S, Huck S, Sieghart W, Cook JM (2008) PWZ-029, a compound with moderate inverse agonist functional selectivity at GABAA receptors containing alpha5 subunits, improves passive, but not active avoidance learning in rats. Brain Res. 1208, 150-159.
Olsen RW and Sieghart W (2008) International Union of Pharmacology. LXX. Subtypes of -Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function—Update. Pharmacol Rev 60: 243-260.
Savic MM, Huang S, Furtmüller R, Clayton T, Huck S, Obradovic DI, Ugresic ND, Sieghart W, Bokonjic DR, Cook JM. (2008) Are GABA(A) receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists? Neuropsychopharmacology. 33, 332-339.
Wulff P, Goetz T, Leppä E, Linden A.-M, Renzi M, Swinny JD, Vekovischeva OY, Sieghart W, Somogyi P, Korpi ER, Farrant M, and Wisden W. (2007) From synapse to behaviour: rapid modulation of defined neuronal populations through engineered GABAA receptors. Nature Neurosci. 10, 923-929
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