Original Publications

Patents

157: Winterberg KJ, Schwentner V, Gu F, Möckl F, Li G, Bauche A, Etzold S, Rosche A, Weiß M, Thuille N, Förster F, Woelk L, Werner R, Kovacevic D, Fehse B, Kurelic R, Nawrocki M, Huber S, Mittrücker HW, Meier C, Müller CE, Baier G, Skålhegg B, de Deken X, Wahl-Schott C, Mair T, Siebels B, Cugota Canals R, Odoardi F, Lodygin D, Flügel A, Nikolaev VO, Diercks B-P, Guse AH. Multiple Signaling Events Are Required for NAADP Synthesis by DUOX2 and Formation of Ca²⁺ Microdomains to Initiate T Cell Activation. Science Signal. 2025; in press.

156: Jukić A, Hilbe R, Zündel L, Willeit P, Faserl K, Plattner C, Zoller A, Meyer M, Siegmund K, Klepsch V, Marteau V, Vich Vila A, Schwärzler J, Vouk K, Kozsar A, Rieder D, Weichberger A, Sarg B, Grabherr F, Mayr L, Moser P, Nemati N, Scholl-Bürgi S, Karall D, Vogel GF, Welz L, Aldrian D, Koch R, Pfister A, Ran Q, Kaser A, Blumberg RS, Tancevski I, Sommer F, Bacher P, Rosenstiel P, Aden K, Baier G, Bakiri L, Müller T, Weiss G, The IBDome Consortium, Weersma RK, Trajanoski Z, Wagner EF, Tilg H, Adolph. TE. Fecal Detection of Calprotectin Dimers Links IBD Activity with Chronicity of Intestinal Inflammation. Gastroenterology 2025 Nov 26, doi: 10.1053/j.gastro.2025.08.040

155: Albrecht-Schöger K, Stefan VE, Steinlechner M, Humer D, Siegmund K, Peer S, Gruber T, Überegger M, zur Nedden S, Baier-Bitterlich G, Lackner P, Schmutzhard E, Thuille N, Klepsch V, Baier G. Inhibition of PKCθ abrogates CD8⁺ T cell–mediated neurotoxicity in murine cerebral malaria. Biomedicines 2025 Oct 22, 13(11), 2582; doi: 10.3390/.                                        
mdpi

154: Stefan VE, Klepsch V, Thuille N, Steinlechner M, Peer S, Siegmund K, Lackner P, Schmutzhard E, Albrecht-Schgör K, Baier G. NR2F6 as a Disease Driver and Candidate Therapeutic Target in Experimental Cerebral Malaria. Cells. 2025 Jul 28;14(15):1162. doi: 10.3390/cells14151162. PMID: 40801595; PMCID: PMC12345861.
Pubmed

153: Humer D, Klepsch V, Baier G. Potentiation of cancer immunogenicity by targeting PARP. J Immunother Cancer. 2025 Jun 24;13(6):e011056. doi: 10.1136/jitc-2024-011056. PMID: 40555563; PMCID: PMC12198780.
Pubmed

152: Jiménez-Lasheras B, Velasco-Beltrán P, Egia-Mendikute L, Pérez-Gutiérrez L, Lee SY, de Blas A, García-Del Río A, Zanetti SR, Antoñana-Vildosola A, Barreira- Manrique A, Bosch A, Etxaniz-Díaz de Durana J, Prieto-Fernández E, Serrano-Maciá M, Goikoetxea-Usandizaga N, Azkargorta M, Elortza F, Gruber T, Peer S, Baier G, Woodhoo A, Martínez-Chantar ML, Palazon A. NEDDylation Regulates CD8+ T-cell Metabolism and Antitumor Immunity. Cancer Immunol Res. 2025 Jul 2;13(7):1004-1021. doi: 10.1158/2326-6066.CIR-24-0127. PMID: 40261130; PMCID: PMC12214884.
Pubmed

151: Woelk J, Hornsteiner F, Aschauer-Wallner S, Stoitzner P, Baier G, Hermann- Kleiter N. Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6. Cell Death Dis. 2025 Feb 7;16(1):77. doi: 10.1038/s41419-025-07407-4. PMID: 39920136; PMCID: PMC11806049.
Pubmed

150: Zur Nedden S, Safari MS, Weber D, Kuenkel L, Garmsiri C, Lang L, Orset C, Freret T, Haelewyn B, Hotze M, Kwiatkowski M, Sarg B, Faserl K, Savic D, Skvortsova II, Krogsdam A, Carollo S, Trajanoski Z, Oberacher H, Zlotek D, Ostermaier F, Cameron A, Baier G, Baier Bitterlich G. Protein kinase N1 deficiency results in upregulation of cerebral energy metabolism and is highly protective in in vivo and in vitro stroke models. Metabolism. 2024 Sep 26;161:156039. doi: 10.1016/j.metabol.2024.156039. Epub ahead of print. PMID: 39332493.

149: Safari MS, Woerl P, Garmsiri C, Weber D, Kwiatkowski M, Hotze M, Kuenkel L, Lang L, Erlacher M, Gelpi E, Hainfellner JA, Baier G, Baier-Bitterlich G, Zur Nedden S. Glucose-1,6-bisphosphate: A new gatekeeper of cerebral mitochondrial pyruvate uptake. Mol Metab. 2024 Oct;88:102018. doi: 10.1016/j.molmet.2024.102018. Epub 2024 Aug 24. PMID: 39182844; PMCID: PMC11404074.

148: Bosch M, Kallin N, Donakonda S, Zhang JD, Wintersteller H, Hegenbarth S, Heim K, Ramirez C, Fürst A, Lattouf EI, Feuerherd M, Chattopadhyay S, Kumpesa N, Griesser V, Hoflack JC, Siebourg-Polster J, Mogler C, Swadling L, Pallett LJ, Meiser P, Manske K, de Almeida GP, Kosinska AD, Sandu I, Schneider A, Steinbacher V, Teng Y, Schnabel J, Theis F, Gehring AJ, Boonstra A, Janssen HLA, Vandenbosch M, Cuypers E, Öllinger R, Engleitner T, Rad R, Steiger K, Oxenius A, Lo WL, Klepsch V, Baier G, Holzmann B, Maini MK, Heeren R, Murray PJ, Thimme R, Herrmann C, Protzer U, Böttcher JP, Zehn D, Wohlleber D, Lauer GM, Hofmann M, Luangsay S, Knolle PA. A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection. Nature. 2024 Jul;631(8022):867-875. doi: 10.1038/s41586-024-07630-7. Epub 2024 Jul 10. PMID: 38987588; PMCID: PMC11269190.

147: Zur Nedden S, Safari MS, Fresser F, Faserl K, Lindner H, Sarg B, Baier G, Baier-Bitterlich G. PKN1 Exerts Neurodegenerative Effects in an In Vitro Model of Cerebellar Hypoxic-Ischemic Encephalopathy via Inhibition of AKT/GSK3β Signaling. Biomolecules. 2023 Oct 31;13(11):1599. doi: 10.3390/biom13111599. PMID: 38002281; PMCID: PMC10669522.

146: Koutník J, Peer S, Humer D, Sumara G, Leitges M, Baier G, Siegmund K. T cell- intrinsic PKD3 fine-tunes differentiation into CD8+ central memory T cells and CD8 single positive thymocyte development. Immunology. 2024 Sep;173(1):125-140. doi: 10.1111/imm.13804. Epub 2024 May 26. PMID: 38798068.

145: Kim H, Feng Y, Murad R, Pozniak J, Pelz C, Chen Y, Dalal B, Sears R, Sergienko E, Jackson M, Ruppin E, Herlyn M, Harris C, Marine JC, Klepsch V, Baier G, Ronai ZA. Melanoma-intrinsic NR2F6 activity regulates antitumor immunity. Sci Adv. 2023 Jul 7;9(27):eadf6621. doi: 10.1126/sciadv.adf6621. Epub 2023 Jul 5. PMID: 37406115; PMCID: PMC10321753.

144: Hornsteiner F, Vierthaler J, Strandt H, Resag A, Fu Z, Ausserhofer M, Tripp CH, Dieckmann S, Kanduth M, Farrand K, Bregar S, Nemati N, Hermann-Kleiter N, Seretis A, Morla S, Mullins D, Finotello F, Trajanoski Z, Wollmann G, Ronchese F, Schmitz M, Hermans IF, Stoitzner P. Tumor-targeted therapy with BRAF- inhibitor recruits activated dendritic cells to promote tumor immunity in melanoma. J Immunother Cancer. 2024 Apr 17;12(4):e008606. doi: 10.1136/jitc-2023-008606. PMID: 38631706; PMCID: PMC11029477.

143: Schoberleitner I, Faserl K, Tripp CH, Pechriggl EJ, Sigl S, Brunner A, Zelger B, Hermann-Kleiter N, Baier L, Steinkellner T, Sarg B, Egle D, Brunner C, Wolfram D. Silicone implant surface microtopography modulates inflammation and tissue repair in capsular fibrosis. Front Immunol. 2024 Mar 19;15:1342895. doi: 10.3389/fimmu.2024.1342895. PMID: 38566997; PMCID: PMC10985323.

142: Koutník J, Leitges M, Siegmund K. T cell-intrinsic protein kinase D3 is dispensable for the cells‘ activation. Front Immunol. 2022 Nov 17;13:1049033. doi: 10.3389/fimmu.2022.1049033. PMID: 36466811; PMCID: PMC9713823.

141: Kim H, Feng Y, Murad R, Klepsch V, Baier G, Ronai Z.
Melanoma-intrinsic NR2F6 activity regulates anti-tumor immunity.
bioRxiv doi: https://doi.org/10.1101/2022.09.14.508028

 

Reviews/Book Chapters

Patents